Benefits of BH4:
This is where I had BH4 sent from:
Before attempting anything, be sure to consult your health professional.
Tetrahydrobiopterin (BH4, THB), also known as sapropterin, is an essential cofactor of natural origin of the three aromatic amino acid hydroxylase enzymes, used in the degradation of the amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin (5-hydroxytryptamine, 5 – HT), melatonin, dopamine, norepinephrine (noradrenaline), epinephrine (adrenaline) and is a cofactor for the production of nitric oxide (NO) by nitric oxide synthases. Chemically, its structure is that of a reduced pteridine derivative.
Sapropterin dihydrochloride can help lower phenylalanine levels in some people with phenylketonuria. It is approved by the FDA for this use along with dietary measures. Most people, however, have little or no benefit.
Tetrahydrobiopterin has the following responsibilities as a cofactor:
Tryptophan hydroxylase (TPH) for the conversion of L-tryptophan (TRP) into 5-hydroxytryptophan (5-HTP)
Phenylalanine hydroxylase (PAH) for the conversion of L-phenylalanine (PHE) to L-tyrosine (TYR)
Tyrosine hydroxylase (TH) for the conversion of L-tyrosine to L-DOPA (DOPA)
Nitric oxide synthase (NOS) for the conversion of a guanidino nitrogen of L-arginine (L-Arg) in nitric oxide (NO)
Alkylglycerol monooxygenase (AGMO) for the conversion of 1-alkyl-sn-glycerol to 1-hydroxyalkyl-sn-glycerol
BH4 also serves as a catalyst for the production of nitric oxide. Among other things, nitric oxide is involved in vasodilation, which improves the systematic blood flow. The role of BH4 in this enzymatic process is so critical that some investigations point to a deficiency of BH4 and, therefore, of nitric oxide, as a central cause of neurovascular dysfunction that is the hallmark of diseases related to circulation , like diabetes.
Apart from PKU studies, tetrahydrobiopterin has been involved in clinical trials studying other approaches to resolve conditions resulting from a tetrahydrobiopterin deficiency. These include autism, ADHD, hypertension, endothelial dysfunction and chronic kidney disease.
In 1997, a small pilot study was published on the efficacy of tetrahydrobiopterin (BH4) in relieving the symptoms of autism, which concluded that "it could be useful for a subgroup of children with autism" and that double-blind trials are needed, such as trials that measure the results over a longer period of time. In 2010, Frye et al. He published a paper that concluded it was safe, and also noted that "several clinical trials have suggested that treatment with BH4 improves the symptomatology of ASD in some people."
Since the production of NO is important in the regulation of blood pressure and blood flow, thus playing an important role in cardiovascular diseases, tetrahydrobiopterin is a possible therapeutic target. In the lining of endothelial cells of blood vessels, endothelial NOS depends on the availability of tetrahydrobiopterin. The increase of tetrahydrobiopterin in endothelial cells by increasing the levels of the biosynthetic enzyme GTPCH can maintain endothelial NOS function in experimental models of pathological states such as diabetes. Atherosclerosis and hypoxic pulmonary hypertension. However, the treatment of patients with existing coronary disease with oral tetrahydrobiopterin is limited by the oxidation of tetrahydrobiopterin to the inactive form, dihydrobiopterin, with little benefit in vascular function
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